If you work with statistics, then you should look at R, an open-source language for statistical analysis. It's jam-packed with features, and has a strong community that offers both assistance and numerous extension packages.
When people talk about big, successful open-source projects, they often think about software that can be used in large organizations. So we hear a great deal about the Linux operating system, the MySQL database, and even Ruby on Rails as a framework for developing Web applications. There's more to the story, though.