Fellow OStatic blogger Mike Gunderloy wrote a great post at Web Worker Daily about his family's experience homeschooling and working from home. In it, he gives some terrific tips about finding a balance between having structure and staying flexible.
As a homeschooling mom who also works full-time from home, there are a number of open source tools I rely on every day to teach my kids and keep us all on task, while keeping myself productive and (relatively) stress-free.