Chemistry 1111. Lab Final Essay. Austin Community College

804 words - 4 pages

Mohammed Lazim Huq
Professor Mohan
Chemistry 1111
May 2, 2018
Isolation of a Blood Vessel Growth Factor research
Over the many decades, there has been considerable research done over Blood Vessel Growth Factor. First, I will explain what a Growth Factor(GF) is. GFs are identified as growth-promoting agents and are identified as a highly purified discrete molecular species. GFs are also known as polypeptides. The actions of GF on cells depends on binding to specific proteins(cell-surface receptors). Mark Bothwell’s research has found that the physiological functions of GF can be derived from their activity in tissue cultures which involve the regulation of cell proliferation and differentiation during embryonic development and wound healing. It has also found that the sequence of amino acids has been determined for many GF polypeptides. The information we gain from this permits a number of GFs to be placed into families, suggesting that they evolved from a single ancestral protein. Families are members of which are related to amino acid sequences. Mark Bothwell’s research has also explained the some of the many different growth factors such as the Nerve growth factor(NGF), Epidermal and Transforming growth factors(EGF&TGF), and Platelet-derived growth factors(PGF). His research over these have found that NGF is produced large amounts in mouse submaxillary gland and in the prostate gland of several mammals. NGF appears to function in promoting survival. EGF is produced in large amounts in the submaxillary gland of male mice. Submaxillary gland EGF is found in a high-molecular-weight aggregate. TGF are a family of factors with similar biological activity. They have been shown to be structurally related to the EGF and are secreted by a variety of cultured cells, mostly tumor cells, they can cause normal fibroblasts to behave like tumor cells. Sometimes the TGF will interact with the EGF cell-surface receptor. PGF is stored in blood platelets and is released during blood clotting. It stimulates fibroblast cell proliferation tissue cultures.
Shang Ma, Hyo Jun Kwon, and Zhen Huang has done research of the development of blood vessels in the early postnatal brain from the compound Astroglia that blocks blood vessel growth. Their research has explained what Astrocytes are and how they affect us. Astrocytes are one of the most abundant cell types in the brain. They play a key role in the normal development and function of the brain’s neural circuitry. Astrocytes intimately interact with the brain’s vascular network. They also tightly ensheath blood vessels through their elaborate perivascular endfeet and perform a nearly-complete covering of brain vessels. Their research also found that in developing the retina, blood vessel growth follows a meshwork laid down by astrocytic processes. This suggests a role of astrocytes in regulating retinal angiogenesis.
An article from the Public Library of Science study tells us about some of the most recent studies of the GDF-15 and FGF-23. Some research has related GDF-15 and FGF-23 with mortality diabetes. GDF-15 is known as Growth differentiation factor-15 and is a member of the TGF beta cytokine superfamily and bone-derived hormone fibroblast GF. GDF-15 is considered as a marker of inflammation and oxidative stress progression of cardiovascular disease. Research has found that having a higher GDF-15 remained a significant predictor of all-cause mortality decline. FGF-23 is known as the fibroblast growth factor-23 and they are two biomarkers reflecting different aspects of renal pathophysiology. Biomarkers have been suggested as risk markers of cardiovascular disease, mortality, and decline in the renal function in the general population FGF-23 is known as a regulator of the phosphate homeostasis by inhibiting the sodium dependent phosphate transporter and thus phosphate reabsorption in the proximal tubule. Higher FGF-23 is perceived as one of the earliest markers of kidney disease. FGF-23 is predominantly secreted by osteocytes.
Overall the research found from all the articles have given me information on how growth factors affect blood vessels and the body. There are many GFs such as NGF, TGF, PGF, EGF, FGF, GDF, and many more unresearched GFs. There is a lot of development in the process of blood vessels. Plus the differentiating factors between GDF and FGF and how they affect us, and what they are. In the future GFs may become the research needed to cure all types of cancer.
Works Cited
Bothwell, Mark. (2014). Growth factor. In AccessScience. McGraw-Hill Education. 2014 ed. [New York]: McGraw-Hill;2012. [Accessed 2018 May 2]
Ma S, Kwon H, Huang Z. A functional requirement for astroglia in promoting blood vessel development in the early postnatal brain. Plos One [serial online]. 2012;7(10):e48001. from: MEDLINE, Ipswich, MA. Accessed May 2, 2018.
Frimodt-Møller M, von Scholten B, Rossing P, et al. Growth differentiation factor-15 and fibroblast growth factor-23 are associated with mortality in type 2 diabetes - An observational follow-up study. Plos One [serial online]. April 26, 2018;13(4):e0196634. Available from: MEDLINE, Ipswich, MA. Accessed May 2, 2018.


Language/Tone Paper The Chrysanthemums - Austin Community College - Essay

1230 words - 5 pages Free Perea 1 Fabian Perea English Composition II 1302. 3 PM T/Th Professor Caraway April 9, 2019 “The Chrysanthemums”: Language & Tone Paper In John Steinbeck's "The Chrysanthemums," Elisa Allen embodies the idea that it is only by revealing ourselves to another person that we are able to experience, and ultimately, develop through our lives. Steinbeck explores this idea of human nature through the multiple aspects by which he uses symbolism; such as

chemistry lab: ferrate both weeks - college general chemistry - Assignment

692 words - 3 pages Free reaction decreases. Correlation of data and hypothesis: As the DTZA was either diluted or concentrated, the line of best fit will also follow the DTZA to see if it increases or decreases. The ferrate and DTZA went back and forth because when the DTZA increased, ferrate decreased and vice versa. REFLECTION I was the manager of my group for this experiment. I explained them the procedure and got the materials we would need for the lab. My partners

astronomy today 7th edition chapter 22 - austin community college - book

1275 words - 6 pages Chapter 22 Multiple Choice 1. A neutron star is about the same size as (a) a school bus; (b) a u.s. city; (e) the Moon; (d) Earth. 2 . A neutron star's immense gravitational attraction is due primarily to its small radius and (a) rapid rotation rate; (b) strong magnetic field; (e) large mass; (d) high temperature. 3. The most rapidly "blinking" pulsars are those that (a) spin fastest; (b) are oldest; (e) are most massive; (d) are hottest. 4. The

English Argumentative Final Essay - Northern Virginia Community College English 112 - Essay

1297 words - 6 pages Belay 1 Rufael Belay Composition II Mr. Perrino 1, August 2019 Defending Net Neutrality The neutrality of the internet has inspired and enabled corporations and individuals to make advancements in applications and services that ultimately contribute to economic growth and progression. Users are entitled to access any lawful content they choose and all internet providers must deal with web traffic fair and equally. The absence of net neutrality

write an essay about a topic to argue - Clovis community college - essay

1533 words - 7 pages community colleges to ivy league universities. Of those 70 percent, 64 percent actually graduate with a degree however, 6 percent end up dropping out entirely. The main concern that comes with committing to a college is the outcome that follows once one graduates. “Will I find a job?” “Will I be overqualified?” “Will I ever pay off my student loans?” “Will I make enough money?”. These are some of the questions that go through a student’s mind when

Profile essay of a event from my country - Suffolk county community college NY - Essay

677 words - 3 pages Free later I took the ESL program (English as a Second Language) at the Suffolk Community College, the first month was so hard because I did not understand very well but then was different everything feels natural, I was learning a lot and I was so proud of myself.             In conclusion, I realized how hard is come to another country where everything is different from mine and how difficult is not to speak the language. I think that experience was

Interpersonal Conflict Final Ppaer - Central Carolina Community College - Paper

444 words - 2 pages My friends and I play poker on a regular basis. One of my friends, let’s call him Tim, constantly plays bad hands and often catches lucky breaks. Tim and I have been friends since middle school, but one night we got into a very big argument which almost became physical. In one particular hand, Tim made what was in my opinion a horribly bad call. Ask most poker players and they will tell you that they would have folded in this situation

Generation Gap between millennia's and baby boomers - Northern Virginia Community college ENG 111 - compare and contrast essay

1378 words - 6 pages 1 Roha Ansar Professor Dr. Casal Compare and Contrast Final English 111 Generation Gap Time always runs and changes the generations, this is one of the biggest truths of life and no one can deny it. Every generation gives something new to the world. As a new baby gradually develops with the flow of time, so does the older generation into a new generation. Children born in the time of 50s or 60s are now the old generation for the children and

Stopping the Woods on a Snowy Evening - Owens Community College - Poetry Final

981 words - 4 pages is some mistake” (lines 9-11). I believe the horse symbolizes intuition and sacrifice. The horse knows this is not something they normally do but he stops anyway to inhale the beauty. In the final stanza he reiterates the beauty of nature but says he has a reality to return to instead of this snowy dream world. “But I have promises to keep, And miles to go before I sleep” (lines 14-15). Although “Desert Places” has the same setting, you get a

Student Success Exploration Paper. In This Essay It Describes My Transition From A 2Yr Community College To A Major University, All Step By Step Explanation With Facts

1888 words - 8 pages Student Success Exploration PaperIn Life there are roads and there are choices. The right or left turn you make along the winding path throughout your life is and should be the one that makes you happy. Furthering your education may be your best and only way to make that right decision. At the present moment I am now currently attending Valencia Community College working towards my Associate Degree in Computer Science. My current major is

contast holden characterization - harford community college - essay

547 words - 3 pages Brandie Lundy 2A English III 8 November 2018 Holden Characterization Characterization is the way in which someone or something is described as a particular type of person or thing in an author’s writing. There are multiple types of characteristics but the main ones determining Holden characteristic are round or flat and dynamic or static. A flat character is a person that do not change and lacks complexity throughout the story. By contrast, round

Argumentative Essay on Healthcare - Bevill State Community College - Argumentative Essay

599 words - 3 pages 1 Alexis Watkins English101 Mrs. Walton 5 October 2017 Health Care Set Up In the world, every country devises its own set of provisions towards meeting the basic objectives of a health care system. In the U.S, the healthcare system faces noteworthy challenges that call for the urgent need for reform. It is evident that Americans in most cases do not receive the care they need even though the money spent by the United States per person on health

Informative Essay on Eating Healthy - Southeastern Community College - Essay

1245 words - 5 pages Fulani 4 Ebony Fulani Marcus Gallagher English 112-I40 July 1, 2019 Does Healthy Eating Effect Lifestyle? Healthy eating should become a part of your life instead of a diet because dieting causes you to limit your food intake and you may be limiting yourself to nutrients that are needed in the body and necessary for strength and maintenance of a healthy body. Making your eating a part of your lifestyle instead of restricting yourself of food

Mending the Relationship of Two brothers - Queensborough Community College - Essay

1176 words - 5 pages Mending the Relationship of Two Brothers in James Baldwin's Sonny's Blues According to Liukkonen, James Baldwin is well known for his "novels on sexual and personal identity, and sharp essays on civil-rights struggle in the United States." "Sonny's Blues" is no exception to this. The story takes place in Harlem, New York in the 1950's and tells of the relationship between two brothers. The older brother, who is the narrator and a participant in

Cinematic Techniques Used in "The Descent" - Portland Community College - Essay

812 words - 4 pages Emily Malech - Week 5 - Walters - ENG 196 Close Reading: The Descent SOUND In most horror films, low pitched sound is used to build up intensity which tells the audience when something bad is about to occur. In other words, we know when something scary is about to happen because the music builds up and gets louder before going completely silent. The Descent uses these techniques commonly throughout the film; the tension and jolt is used when the