Crispr( Clustered Regularly Interspaced Short Palandromic Syndromes) Bergen College Essay

763 words - 4 pages

Manish Lamichhane
Dr. Galvez
Writing 101
CRISPR
CRISPR stands for Clustered Regularly Interspaced Short Panildromic Repeats is a Cas system in prokaryotes which is guided by a RNA and it aids in dematerializing foreign nucleic acids. CRISPR is a new technology where a Cas-9 is used which can modify the genes of the organisms. CRISPR has the ability to rearrange the genetic sequence of the DNA of living organisms (Michael Specter, Nat Geo). Even though CRISPR is capable of editing genetic sequence but according to research on different organisms it is also responsible for different genetic mutations which may cause muscular dystrophy and cystic fibrosis and many genetic disorders (Michael Specter, Nat Geo). CRISPR might be one of the beneficial things to us but its misuse will certainly give rise to many issues. The misuse of CRISPR can cause ecological disequilibrium, transhumanism and unpredictable environmental effect.
CRISPR is guided by RNA and there are many possible outcomes of mutations which might carry from one generation to another destroying the natural genetic sequence of the organisms making organisms deprived of their heritable traits and characters which will disturb the ecology (Rodriguez E, University of Chile). There is always an ethical issue arising that there might be greater risks of CRISPR than its benefits (Rodriguez E, University of Chile).There is a high risk of passing a gene with a negative trait to another organism beyond the borders (Esvelt KM, Catteruccia F, Smilder AL GM Church 2014).The gene flow of the organisms will be very difficult to control causing a drastic disequilibrium in ecology. There might be an accidental release of the organisms that are modified using CRISPR technology (Oye KA, Catteruccia F, Esvelt K, Appleton E, Church G, et al. (2014)). It requires a very precise research and safety measures to avoid any ecological disequilibrium.
Secondly, there are many therapeutic interventions in the somatic cells of the human using the genome editing technology which can significantly affect the germline of the human (Ding C, Huang R, Liang P). Due to the genome editing technology on the human germline the genome can be passed from one generation to another, to form eggs, gametes and embryos raising a serious ethical questions and issues (Otieno MO,...

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