1. What factors place an infant and child at risk when prescribing medications?
1. Inattention to weight based dosing increases potential for harm.
2. Immature organ function, renal and hepatic
3. Limited study on medication use in children
2. What adverse drug reactions (ADRs) are the elderly at risk of developing?
1. Toxicity secondary to decreased renal and hepatic function which causes decreased clearance and metabolism.
2. Polypharmacy risk due to drug to drug interaction
3. Unintentional overdose.
3. What are the ADRS related to special populations?
1. Geriatric Population:
1. Slowed absorption and clearance
1. Decreased GI acidity, motility
2. Reduced hepatic and renal function
3. Body composition
1. Decreased mass, increased fat
5. Reduced activity levels
6. Less effective blood brain barrier
2. Pediatric Population:
1. Immature Organs
1. Hepatic and renal function are reduced
1. Reduced glomerular filtration
2. Decreased tubular secretion and reabsorption
2. Blood brain barrier immature
3. Pregnant Population:
1. Hormonal Impact
1. Decreased GI tone, gastric emptying, and peristalisis
1. Increase tidal volume
2. Pulmonary vasodilation
3. Increased absorption of inhaled drugs
4. Inhaled drug absorption is increased
1. Increased heart rate
2. Increased circulatory volume
1. Hypoalbuminemia due to dilution
3. Increased plasma lipid levels
1. Impacts transport/distribution of drugs
4. Impact on fetus
1. Non-lipophilic drugs enter fetal circulation
2. Potential for medications to enter breastmilk
4. Which medications interact with St. John’s Wort?
1. Warfarin, antidepressants, antiretrovirals, CNS depressants, analgesics, phenytoin
5. How does doxazosin work?
1. Doxazosin relaxes the...