Prilosec, also known as omeprazole, is a compound that inhibits gastric acid secretion.
Omeprazole was first marketed in the United States in 1989 by Astra AB, now AstraZeneca,
under the brand name Losec. In 1990, at the request of the U.S. Food and Drug Administration,
the brand name Losec was changed to Prilosec to avoid confusion with the diuretic Lasix
(furosemide). The appearance is a peachy, grainy color, and it costs around $1.70 a pill.
Dangers and side effects include allergic reactions such as hives; difficulty breathing;
swelling of your face; low magnesium (dizziness, confusion, fast or uneven heart rate, jerking
muscle movements, muscle cramps, seizure), tachycardia, an abnormally rapid heart rate.
Furthermore, in clinical trials, omeprazole and esomeprazole have only rarely been associated
with hepatic injury. In large scale, long term trials , serum ALT elevations, (ALT is used to break
down food into energy. Normally, ALT levels in the blood are low. If your liver is damaged, it
will release more ALT into your blood and levels will rise. (ALT used to be called serum
glutamic-pyruvic transaminase, or SGPT), simply, the liquid part of your blood), occurred in less
than 1% of patients and at rates similar to those that occurred with placebo or comparator drugs.
A small number of cases of clinically apparent liver disease due to omeprazole or
esomeprazole have been published, the frequency of these cases probably being less than
1:100,000 users. A somewhat characteristic clinical phenotype has been described, with most
cases arising during the first 1 to 4 weeks of therapy and being marked by an acute
hepatocellular(pertaining or affecting liver cells)pattern of injury, with rapid recovery upon
withdrawal. Rash, fever and eosinophilia were rare, as is autoantibody formation.
Liver biopsy typically shows predominant centrilobular necrosis, suggestive of an acute,
toxic hepatic injury (acute hepatic necrosis); however, recurrence upon rechallenge has been
documented in several cases. In some instances, other organ involvement is prominent including
rhabdomyolysis, lactic acidosis, renal insufficiency or Stevens Johnson syndrome. In large case
series of drug induced liver injury, omeprazole and esomeprazole have accounted for few
instances of symptomatic acute liver injury and rare instances of acute liver failure.
The formula: C17H19N3O3S, with a molecular weight of 345 amu. The solubility is 0.25
mg/mL in water at 25°C. Dosage of omeprazole differentiates based on the complication of the
patient. For example, treatment of an Active Benign Gastric Ulcer is 40 gm once daily for 4 to 8
weeks. While the treatment of an Active Duodenal Ulcer is 20 gm once daily for 4 weeks.
More on Centrilobular Necrosis
Necrotic hepatocytes around central vein, usually due to ischemia, drugs or toxins. Common
finding at autopsy because it is associated with circulatory failure or...