What Do U Know About Cytotec Aka Misoprosto

317 words - 2 pages

Chse 235 Efosa AsemotaDrug report #2 Cytotec/ MisoprostoTherapeutic categoryMucosal Protective gent Use/ indicatorFor the treatment and prevention of NSAID-induced gastroduodenal ulcers. Also indicated for the treatment of duodenal ulcers caused by Peptic Ulcer Disease (PUD).Adverse reactionThe most frequent gastrointestinal adverse events were diarrhea (10.7%), abdominal pain (7.3%), nausea (4.2 ...view middle of the document...

In patients receiving placebo, the incidence of diarrhea was 3.6%. The events were usually transient and mild to moderate in severity.Contraindication/overdosePossible clinical signs that may indicate an overdose may include: sedation, tremor, fever, convulsions, dyspnea, abdominal pain, diarrhea, palpitations, hypotension or bradycardia. Treatment should be symptomatic and supportive. Children: Safety and effectiveness in patients below the age of 18 have not been established. Known sensitivity to prostaglandins, prostaglandin analogues or excipients (microcrystalline and hydroxypropyl methylcellulose, sodium starch glycolate and hydrogenated castor oil). Contraindicated in pregnancy.Initial dosageThe recommended adult oral dosage for the prevention and treatment of NSAID-induced gastroduodenal ulcer is 400 to 800 µg a day in divided doses. NSAIDs should be taken according to the schedule prescribed by the physician. When appropriate, misoprostol and NSAIDs are to be taken simultaneously. Misoprostol should be taken after food.Reference:www.drugs.com, www.pharmclips.com, http://www.rxmed.com,http://www.rxmed.com/b.main/b2.pharmaceutical/b2.prescribe.html


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